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Wait 20-30 minutes to make sure that your skin is completely dry Remember, RETIN A CREAM will not work overnight. For optimal results, use on a regular basis. FDA Pregnancy Category D. DailyMed; DrugBank tretinoin . 84:16 cell stimulants and proliferants. Black Box warning for severe birth defects; Special FDA distri-. 5% Using too much could lead to inflammation, redness of the skin, and make hyperpigmentation worse than ever.

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