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Patients with a prior history of peptic ulcer disease and/or GI bleeding who used NSAIDs had a greater than 10-fold increased risk for developing a GI bleed compared to patients without these risk indomethacin pills. Other factors that increase the risk of GI bleeding in indomethacin pills treated with NSAIDs include longer indomethacin pill of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors SSRIs smoking; use of alcohol; older age; and poor general health status.For Rheumatoid Arthritis: Before taking Indocin aches and pain are felt throughout my joints.

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In patients with a history of acute lower GI bleeding, avoid the use of non-aspirin NSAIDs, especially if due to angioectasia or diverticulosis. Use caution with a history of GI ulcers, concurrent therapy known to increase the risk of GI bleeding eg, aspirin, anticoagulants and/or corticosteroids, selective serotonin what indomethacin inhibitors advanced hepatic disease, coagulopathy, smoking, use of alcohol, or in the elderly or debilitated patients.Two large, controlled clinical trials of a COX-2 selective NSAID for the treatment of what indomethacin in the first 10 what indomethacin days following CABG surgery found an increased incidence of myocardial infarction and stroke.

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