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Indometacin
Clinical data
Pronunciation/ ɪ n d oʊ ˈ m ɛ t ə s ɪ n /
Trade namesIndocid, Indocin
AHFS/Drugs.comMonograph
License dataUS   FDA: Indomethacin
Pregnancy categoryAU: C C/D (US)
Routes of administrationOral, rectal, IV, topical
ATC codeC01EB03 ( WHO ) M01AB01 ( WHO ), M02AA23 ( WHO ), S01BC01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~100% (oral), 80–90% (rectal)
Protein binding99% [1]
MetabolismHepatic
Elimination half-life2.6-11.2 hours (adults), 12-28 hours (infants) [1]
ExcretionRenal (60%), fecal (33%)

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Careful instructions to, and observations of, the individual patient are essential to the prevention of serious, irreversible, including fatal, adverse reactions.Therefore, every effort should be made to determine the lowest effective dosage for the individual patient.

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Reverted to Advil.While the association between NSAID use and minimal hemicrania continua indomethacin dosage glomerulonephropathy inflammation of kidney nerve fibers has been recognized, a recent study suggests that nephrotic syndrome due to membranous nephropathy should also be recognized as a possible reaction to NSAID use.

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This medicine does not prevent heart attack or stroke.erious side effects of Indocin may include hemicrania continua indomethacin dosage attack, stroke, skin changes paleness, blisters, rash, and hives weight gain, swelling, shortness of breath, tachycardia, unusual bleeding including GI bleeding jaundice, stomach pain, and pain with urination, bloody urine, blurry vision, and back pain.

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Caution should be used when NSAIDs are administered concomitantly with methotrexate. The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both indomethacin doses for hemicrania continua together have a risk of serious GI bleeding higher than indomethacin doses for hemicrania continua of either drug alone.However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke usually at dosages of 81-325 milligrams a day you should continue taking the aspirin unless your doctor instructs you otherwise.

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Van Overmeire B, Follens I, Hartmann S, Creten WL, Van Acker KJ. Treatment of hemicrania continua indomethacin dosage ductus arteriosus with ibuprofen.Honestly, the one that works best for you. If you are in a lot of pain, an NSAID that you take more often might give you more relief spread out throughout the day.

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