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Clinical data
Pronunciation/ ɪ n d oʊ ˈ m ɛ t ə s ɪ n /
Trade namesIndocid, Indocin
License dataUS   FDA: Indomethacin
Pregnancy categoryAU: C C/D (US)
Routes of administrationOral, rectal, IV, topical
ATC codeC01EB03 ( WHO ) M01AB01 ( WHO ), M02AA23 ( WHO ), S01BC01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~100% (oral), 80–90% (rectal)
Protein binding99% [1]
Elimination half-life2.6-11.2 hours (adults), 12-28 hours (infants) [1]
ExcretionRenal (60%), fecal (33%)

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Careful instructions to, and observations of, the individual patient are essential to the prevention of serious, irreversible, including fatal, adverse reactions.Therefore, every effort should be made to determine the lowest effective dosage for the individual patient.

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Reverted to Advil.While the association between NSAID use and minimal hemicrania continua indomethacin dosage glomerulonephropathy inflammation of kidney nerve fibers has been recognized, a recent study suggests that nephrotic syndrome due to membranous nephropathy should also be recognized as a possible reaction to NSAID use.

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This medicine does not prevent heart attack or stroke.erious side effects of Indocin may include hemicrania continua indomethacin dosage attack, stroke, skin changes paleness, blisters, rash, and hives weight gain, swelling, shortness of breath, tachycardia, unusual bleeding including GI bleeding jaundice, stomach pain, and pain with urination, bloody urine, blurry vision, and back pain.

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