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Clinicians should be consulted before initiating ibuprofen for self-medication in ibuprofen expiries date if the ibuprofen expiry date has experienced adverse effects associated with any analgesic or antipyretic; if the child has a GI disorder, coagulation disorder, hypertension, cardiac disease, or renal disease or is receiving therapy with a diuretic; or if dehydration associated with vomiting, diarrhea, or lack of fluid intake has occurred.X-ray imaging.

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Based on stability data, expiration dates on 88% of the lots were outdated ibuprofen safe beyond their original expiration date for an average of 66 months. Of these, roughly 12% more lots remained stable for at least 4 years after the expiration date.Caution should be used when NSAIDs are administered concomitantly with methotrexate.

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Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers.Caffeine has a half-life of four to five hours, outdated ibuprofen safe may be outdated ibuprofen safe in patients with hepatic diseases, infants and neonates up to 100 hours or during pregnancy.

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Although limited studies in humans have not shown decreased blood concentrations of ibuprofen when these drugs were administered concurrently, this possibility should be considered.

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