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StatPearls publishing.Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product. Concomitant use of opioids with benzodiazepines or other central nervous system CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
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19 September 2008.The usual recommended maximum 24-hour dosage of acetaminophen is 4, 00 mg.
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