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Paracetamol
Clinical data
PronunciationParacetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )
Trade namesTylenol, Panadol, others [2]
AHFS/Drugs.comMonograph
MedlinePlusa681004
License dataUS   FDA: Acetaminophen
Pregnancy categoryAU: A US: C (Risk not ruled out) [1] Not tested but seems to be safe
Routes of administrationBy mouth, through the cheek, rectal, intravenous (IV)
ATC codeN02BE01 ( WHO )
Legal status
Legal statusAU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability63–89% [4] : 73
Protein binding10–25% [5]
MetabolismPredominantly in the liver [3]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6]
Onset of actionPain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7]
Elimination half-life1–4 hours [3]
ExcretionUrine (85–90%) [3]

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pain, the health care provider may first suggest over-the-counter OTC pain medicines such as aspirin NIH external link or acetaminophen NIH external link. Acad Emerg Med. 2014 Opioid-Prescribing Patterns of Emergency Physicians and Risk of Long-Term Use. Michael L. Barnett, M. Andrew R. Olenski, B. and Anupam B. Jena, M. Ph. N Engl J Med. 63-673values of the glucoronosyl tranferases.

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As a group, antidepressants and anti-seizure medications may, rarely, worsen depression or cause suicidal thoughts.Read the label carefully for proper dosage, and be careful not to take more than one medication containing acetaminophen, such as some cough and cold medicines.

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Drink alcohol heavily 3 or more drinks a day for men and 2 or more drinks a day for women Author: Healthwise StaffMedical Review: William H. Blahd Jr. MD, FACEP - Emergency MedicineJohn Pope MD - PediatricsKathleen Romito MD - Family MedicineAdam Husney MD - Family MedicineMartin J. Gabica MD - Family MedicineDavid Messenger MD Medical Review: illiam H.

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